So you are planning to visit Marches, a little region of Italy on the Adriatic Sea. The Marches (it's often spelled with The) is relatively unknown to tourists. This is a great place to see the real Italy. Sights to see include the college town of Urbino with a lovely Palazzo Ducale that houses the Galleria Nazionale delle Marche and the Casa Natale de Raffaello, the house in which Raphael was born. While the National Gallery doesn't contain much work by Raphael, you may enjoy Titian's Resurrection and Last Supper.
The coastal city of Pesaro has the usual (for Italy) components of Ducal Palace, Cathedral, castle, churches, and museums. One museum is devoted to a local boy, the opera composer Rossini. Head further down the coast to the port of Ancona and visit the Duomo di San Ciriaco (Cathedral). Stroll the streets of the old city. Loreto is home to the Santuario della Santa Casa (House of the Virgin Mary). Festival time is Easter week and December 10, the Feast of the Holy House. Finish your tour at Ascoli Piceno. Visit the Piazza del Populo (Square of the People) and the Thirteenth Century Palazzo dei Capitani del Populo (Palace of the People's Captains). Festival time is the first Sunday in August, a day devoted to the city's patron saint, Saint Emidio.
Marches, tucked between the Appennine Mountains and the Adriatic Sea, produces two top of the line wines, Rosso C